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High affinity interaction of mibefradil with voltage-gated calcium and sodium channels

✍ Scribed by Philipp Eller; Stanislav Berjukov; Siegmund Wanner; Irene Huber; Steffen Hering; Hans-Günther Knaus; Geza Toth; S David Kimball; Jörg Striessnig


Book ID
110005030
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
222 KB
Volume
130
Category
Article
ISSN
0007-1188

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Solution structure of maurotoxin, a scor
✍ E. Blanc; J.M. Sabatier; R. Kharrat; S. Meunier; M. El Ayeb; J. Van Rietschoten; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 488 KB 👁 2 views

Maurotoxin (MTX), purified from the scorpionid Scorpio maurus is a potent ligand for potassium channels. It shows a broad specificity as being active on Kv1.1 (Kd ‫؍‬ 37 nM), Kv1.2 (Kd ‫؍‬ 0.8 nM), Kv1.3 (Kd ‫؍‬ 150 nM) voltage-gated potassium channels, as well as on small-conductance calcium-activa