๐”– Bobbio Scriptorium
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High affinity insulin binding and insulin receptor-effector coupling: Modulation by Ca2+

โœ Scribed by P.F. Williams; I.D. Caterson; G.J. Cooney; R.R. Zilkens; J.R. Turtle


Book ID
113236499
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
997 KB
Volume
11
Category
Article
ISSN
0143-4160

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Insulin receptors are disulfide-linked oligotetramers composed of two heterodimers each containing a 130-kDa 01 subunit and a 90-kDa p subunit. Insulin binds to the extracellular 01 subunit, and in the process stimulates the autophosphorylation of the p subunit and the expression of tyrosine kinase