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High-affinity Human Antibodies from Phage-displayed Synthetic Fab Libraries with a Single Framework Scaffold

✍ Scribed by Chingwei V Lee; Wei-Ching Liang; Mark S Dennis; Charles Eigenbrot; Sachdev S Sidhu; Germaine Fuh

Book ID
116661377
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
529 KB
Volume
340
Category
Article
ISSN
0022-2836

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## Abstract Compelling evidence suggests that vascular endothelial growth factor (VEGF) and its receptors play an important role in angiogenesis associated with tumor growth and metastasis. VEGF exerts its biologic activities through 2 transmembrane tyrosine kinase receptors: the __fms__‐like tyros