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High-Affinity Binding of Tumor-Suppressor Protein p53 and HMGB1 to Hemicatenated DNA Loops †

✍ Scribed by Štros, Michal; Muselíková-Polanská, Eva; Pospíšilová, Šárka; Strauss, François


Book ID
126076759
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
283 KB
Volume
43
Category
Article
ISSN
0006-2960

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula