High affinity as a disease determinant factor in anti-GM1 antibodies: comparative characterization of experimentally induced vs. disease-associated antibodies

High affinity of anti-GM1 antibodies is

High affinity of anti-GM1 antibodies is associated with disease onset in experimental neuropathy

✍ Romina Comín; Nobuhiro Yuki; Pablo H.H. Lopez; Gustavo A. Nores 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB

## Abstract High antibody affinity has been proposed as a disease determinant factor in neuropathies associated with anti‐GM~1~ antibodies. An experimental model of Guillain‐Barré syndrome, induced by immunization of rabbits with bovine brain gangliosides or GM~1~, was described recently (Yuki et a