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HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cells

✍ Scribed by Alexander Weidemann,Johannes Breyer,Margot Rehm…

Book ID
126376352
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
892 KB
Volume
11
Category
Article
ISSN
1478-811X

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## Abstract α4β1 integrin is highly expressed in lymphocytes and is essential in hematopoiesis, extravasation, and the inflammatory response. α4β1 can be activated by intracellular signals elicited upon T‐cell activation by phorbol esters, CD3 crosslinking, or certain chemokine/receptor interaction