Hierarchically mesoporous–macroporous bioactive glasses scaffolds for bone tissue regeneration

✍ Scribed by Hui-suk Yun; Seung-eon Kim; Yong-taek Hyun; Su-jin Heo; Jung-wook Shin

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 468 KB
• Volume: 87B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31114

✦ Synopsis

Abstract

Hierarchically 2D/3D mesoporous–macroporous bioactive glasses (MMBG) with good molding capabilities and compressive modulus were synthesized by sol–gel method and evaporation‐induced self‐assembly process in the presence of both nonionic triblock copolymers, EO~70~PO~20~EO~70~ (P123) or EO~100~PO~65~EO~100~ (F127), templates and methyl cellulose template. P123 or F127 acts as both a template, inducing the formation of mesopore, and an effective dispersant of MC, which produces macropores. In vitro bioactivity studies were carried out in simulated body fluid and showed superior bone‐forming bioactivities of hierarchical MMBG. Human osteoblastlike cells, MG63, were seeded on MMBG and were determined using MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5,‐diphenyl‐tetrazolium bromide] assay to confirm biocompatibilities of MMBG. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008