Hierarchical structure in polymer-based drug delivery systems as probed by calorimetric measurements
✍ Scribed by Pascale Valot; Nathalie Sintes-Zydowicz; Jean-Marie Nedelec; Mohamed Baba
- Book ID
- 105339435
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 767 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0887-6266
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Thermoporosimetry (TPM), a differential scanning calorimetry technique that relies on the shift of transition temperatures caused by the confinement of liquids, was applied to elucidate the complex morphology of drug‐loaded polymeric microcapsules prepared by the emulsion solvent evaporation method. For the very first time, TPM has been applied simultaneously with two liquids as structural probes. It was found that Miglyol, which dissolves the selected drug (Ibuprofen), is confined inside vesicles having a mean radius of 26.3 nm, whereas water, which is the continuous phase, is trapped inside a swollen polymeric network of Eudragit with an average mesh radius of 1.7 nm. A proposed hierarchical structure is given, which predicts that Eudragit microcapsules are formed from a collection of inert oil vesicles partitioned by polymeric Eudragit membranes swollen by water. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 48: 1939–1945, 2010