We read with interest the article recently published in HEPATOLOGY, 1 which suggested that heterozygosity for hemochromatosis C282Y mutation could be associated with more fibrosis in patients with chronic active hepatitis (CAH) owing to hepatitis C virus (HCV). Liver iron accumulation has been obser
✦ LIBER ✦
HFE C282Y mutations are associated with advanced hepatic fibrosis in Caucasians with nonalcoholic steatohepatitis
✍ Scribed by James E. Nelson; Renuka Bhattacharya; Keith D. Lindor; Naga Chalasani; Stuart Raaka; E. Jenny Heathcote; Emil Miskovsky; Eldon Shaffer; Stephen J. Rulyak; Kris V. Kowdley
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 295 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0270-9139
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Viral genotyping was performed in 61 patients with untreated chronic hepatitis C using the Inno-Lipa HCV II assay (Innogenetics, Zwijnaarde, Belgium). Steatosis was graded as previously reported. 1 The association between viral genotype and steatosis was tested using the Pearson' s 2 statistic and t