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HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

✍ Scribed by Abdul Waheed; Robert S. Britton; Jeffrey H. Grubb; William S. Sly; Robert E. Fleming


Book ID
116178147
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
336 KB
Volume
474
Category
Article
ISSN
0003-9861

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The role of Hfe in transferrin-bound iro
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HFE-related hereditary hemochromatosis results in hepatic iron overload. Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by th