Heterotransplantation of human cervix cancers in radiation-conditioned or nonconditioned athymic mice

✍ Scribed by Yosh Maruyama; Jose M. Feola; John R. van Nagell

• Book ID: 101327280
• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 452 KB
• Volume: 56
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19851201)56:11<2635::aid-cncr2820561117>3.0.co;2-l

✦ Synopsis

Primary human cervix cancers were implanted into athymic nude mice from 23 patient biopsy specimens. Tissue/tumor samples were implanted as chunks by trochar in different sites in irradiated (400 rad) or nonirradiated nude mice. Without irradiation 1 of 9 (11%) implanted tumors grew progressively and 13 of 26 (50%) implanted sites formed small implantation nodules that remained stable and usually regressed. In nude mice given 400-rad irradiation, 3 of 12 (25%) showed progressive tumor growth, 8 of 12 (67%) patient samples showed growth, and 24 of 36 (67%) implanted sites showed growth. Correlation with clinical data showed that the higher-stage and more malignant tumors were more likely to show progressive growth patterns, as was noted in three of five Stage III/IV cervix tumors grafted into 400-rad conditioned mice. Conversely, the lower-stage tumors were much less likely to show growth, and zero of nine samples with Stage 1/11 tumors showed progressive growth.