✦ LIBER ✦
Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism
✍ Scribed by Alan P. Kypson; Emilie Morphew; Relief Jones; Marcia R. Gottfried; Hilliard F. Seigler
- Book ID
- 102439919
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 289 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
✦ Synopsis
The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.