## Abstract The p38 MAPKs are a family of kinases that regulate a number of cellular functions including cell migration, proliferation, and differentiation. Here, we report that p38 regulates oligodendrocyte differentiation. Inhibition of p38 with PD169316 and SB203580 prevented accumulation of pro
β¦ LIBER β¦
Heterosis for myelin content is limited to the central nervous system
β Scribed by R. Miskimins; R. K. Yu
- Book ID
- 102386012
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 282 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0360-4012
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β¦ Synopsis
We have recently described a murine model for studying aspects of myelination (Seyfried and Yu, 1980;Ebato et al., 1983;Miskimins et al., 1986). This mouse shows hypermyelination during the period of most active synthesis of myelin, 9 to 21 days post-natal. The myelin parameters showing an increase were all measured in the central nervous system. We investigated here whether this effect extends into the peripheral nervous system. Our results indicate that the hypermyelination is limited to the central nervous system.
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