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Heterogeneity of clonal development in chronic myeloproliferative disorders

✍ Scribed by Ferraris, Anna Maria; Mangerini, Rosa; Racchi, Omar; Rapezzi, Davide; Rolfo, Michela; Casciaro, Salvatore; Gaetani, Gian Franco

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 86 KB
Volume: 60
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199902)60:2<158::aid-ajh14>3.0.co;2-9

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✦ Synopsis

Recent reports have suggested a previously unexpected variability in the expression of the dominant neoplastic clone in myeloproliferative disorders (MPD). We evaluated 49 female patients with MPD and informative at the X-linked androgen receptor (AR) locus to establish the X chromosome inactivation pattern of hemopoietic cells. Whereas in chronic myelogenous leukemia (CML) the granulocytes (PMN) were uniformly of monoclonal origin, a striking heterogeneity of clonal development was found in PMN from patients with other MPD, with up to 50% of them expressing a polyclonal pattern of X inactivation. Am.

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