Heterogeneity of monoclonal antibodies
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Hongcheng Liu; Georgeen Gaza-Bulseco; Dinesh Faldu; Chris Chumsae; Joanne Sun
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Article
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2008
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John Wiley and Sons
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English
β 211 KB
Heterogeneity of monoclonal antibodies is common due to the various modifications introduced over the lifespan of the molecules from the point of synthesis to the point of complete clearance from the subjects. The vast number of modifications presents great challenge to the thorough characterization