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Heterogeneity in Wiedemann-Beckwith syndrome: Anthropometric evidence

✍ Scribed by Moore, Elizabeth S.; Ward, Richard E.; Escobar, Luis F.; Carlin, Mary E.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 72 KB
Volume: 90
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000214)90:4<283::aid-ajmg4>3.0.co;2-f

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✦ Synopsis

Wiedemann-Beckwith syndrome (WBS) has attracted a great deal of attention because of its genetic complexity. Individuals with WBS can be identified objectively by anthropometric analysis. Craniofacial anthropometry in conjunction with multivariate statistical analysis can be used to define patterns of variability that appear to relate to specific modes of inheritance that have been proposed for WBS. Our data on 19 affected individuals and their first-degree relatives indicate that the pattern of inheritance rather than the age of subjects may be responsible for the highly variable craniofacial phenotype found in individuals diagnosed with WBS.

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