Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0) as revealed by HindIII restriction fragment length polymorphism analysis

A marked drop in the incidence of the nu

A marked drop in the incidence of the null allele of the B gene of the fourth component of complement (C4B*Q0) in elderly subjects: C4B*Q0 as a probable negative selection factor for survival

✍ Judit Kramer; Tamás Fülöp; Katalin Rajczy; Nguyen Ahn Tuan; George Füst 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 395 KB

The incidence of allotypes of the genes of the fourth component (C4) and factor B of the complement system was compared in 252 persons under 45 years of age ("young" group) with 482 people between 61 and 90 years of age ("old" group). One hundred people older than 90 years of age (nonagenarians) wer