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Heterogeneity in the map distance between X-linked agammaglobulinemia and a map of nine RFLP loci

✍ Scribed by J. Ott; E. J. B. M. Mensink; A. Thompson; J. D. L. Schot; R. K. B. Schuurman

Publisher: Springer
Year: 1986
Tongue: English
Weight: 380 KB
Volume: 74
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00282549

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✦ Synopsis

In nine family pedigrees in which X-linked agammaglobulinemia (XLA) is segregating, a multi-point linkage analysis has been carried out. In each family, the map distance, d, between XLA and a fixed point in a known map of nine RFLP loci on the X chromosome was estimated by calculating the log likelihoods, L(d). Using a new method, the 10-point likelihood was approximated by appropriately combining three 4-point likelihoods. Homogeneity tests (admixture tests) were performed showing clear evidence for heterogeneity of XLA.

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