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Heterogeneity in the composition of commercial heparins: Comparison of anticoagulant activities and biochemical compositions of anionic density-fractionated heparins

โœ Scribed by Robert E. Hurst; Juanita M. Settine; Man-chiu Poon; Aubrey Lurie

Book ID
119034912
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
776 KB
Volume
25
Category
Article
ISSN
0049-3848

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The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified