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Heterogeneity in osteosarcoma cell lines and the biological effects of the chemical structure of 25-hydroxyvitamin D3 and 1 a,25 dihydroxyvitamin D3

✍ Scribed by Charalampos Dokos; Andreas H. Groll

Book ID: 112134398
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 44 KB
Volume: 30
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.22155

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## Abstract The differentiating and antitumor activities of 1α,25‐dihydroxyvitamin D~3~ (1α,25(OH)~2~D~3~) in vitro and 1α‐hydroxyvitamin D~3~ (1α(OH)D~3~) in vivo were studied with a human osteosarcoma cell line (OST strain). Antitumor activity was estimated with the use of 3‐(4,5‐dimethylthiazol)