Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients
✍ Scribed by Cecilia M. Borromeo; Xavier Pottier; Peter A. In’t Veld; Miriam A. Pipeleers-Marichal; Leonard Kaufman; Daniel G. Pipeleers; Christiaan F. Van Schravendijk
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 193 KB
- Volume
- 446
- Category
- Article
- ISSN
- 1432-2307
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Quantitative morphometry of the pancreases of five 'maturity-onset' diabetic subjects has demonstrated more amyloid in islets of the head, body and tail (where it was found in a mean 29% of the islets occupying a mean 11% islet area) than in islets of the 'pancreatic-polypeptide-rich' lobule of the
Islet amyloid polypeptide is the major protein component of the islet amyloid of patients with Type 2 (noninsulin-dependent) diabetes mellitus. Since the synthesis of a structurally abnormal or mutant protein may contribute to the formation of amyloid deposits, we have examined the possibility that
Fasting plasma islet amyloid polypeptide concentrations and their responses to an oral glucose load were determined in non-diabetic control subjects and patients with abnormal glucose tolerance in relation to the responses of insulin or C-peptide. Plasma islet amyloid polypeptide was measured by rad