Heterogeneity in antigenic expression and radiosensitivity in human colon carcinoma cell lines
✍ Scribed by Gunilla Frykholm; Bengt Glimelius; Sven Richter; Jörgen Carlsson
- Book ID
- 112801706
- Publisher
- Society for In Vitro Biology
- Year
- 1991
- Tongue
- English
- Weight
- 883 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1475-2689
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## Abstract The levels of expression of phosphoinositide‐specific phospholipase Cs (PLCs) were examined in a series of primary human colon carcinomas and in eight colon carcinoma cell lines by using monoclonal antibodies and cDNA probes for PLCγ1, PLCβ1, and PLCδ1. Western and northern blot analyse
Previous studies have established that colon carcinoma cells secrete several polypeptide growth factors, including TGF-dEGF and TGF-B, suggesting that these and related molecules function in an autocrindparacrine fashion to modulate tumor-cell growth. To investigate this possibility, we have studied