## Abstract Treatment of 4‐chloro‐5__H__‐1,2,3‐dithiazole‐5‐thione with alkyl 3‐alkyl (or aryl)‐3‐amino‐2‐propenoates in the presence of pyridine (2 equivalents) in dichloromethane at reflux gave 2‐[2‐(1‐alkenylsulfanyl‐1‐alkoxy‐carbonyl‐2‐amino)‐1,2‐dicyanovinylsulfanyl]‐**4** and‐1,2‐dicyanovinyl
Heterocyclization of thiol esters ofα-aminocarboxylic acids with the formation of 5-alkylthio-Δ4-1,3,2-oxazaphospholines
✍ Scribed by Yu. G. Gololobov; L. I. Kruglik
- Book ID
- 112447395
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 163 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1573-9171
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## Abstract 4‐(Dicyanomethylene)‐3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one (1) readily reacts with α‐amino acids and their esters by Michael addition and subsequent elimination of HCN to the adducts 2a–k. One of these, 2i (obtained from methyl glycinate), adds stereoselectively to __N__‐phenylmaleimide