Heterocyclic Compounds: Synthesis, Properties and Applications

✍ Scribed by Kristian Nylund, Peder Johansson, Z. Puterova, A. Krutosikova, D. S. Zurabishvili, M. O. Lomidze, Sh. A. Samsoniya

• Publisher: Nova Science Publishers, Inc.
• Year: 2010
• Tongue: English
• Leaves: 403
• Series: Chemistry Research and Applications
• Category: Library

✦ Synopsis

Heterocyclic compounds are organic compounds containing at least one atom of carbon, and at least one element other than carbon, such as sulphur, oxygen or nitrogen within a ring structure. These structures may comprise either simple aromatic rings or non-aromatic rings. Some examples are pyridine (C5H5N), pyrimidine (C4H4N2) and dioxane (C4H8O2). Many heterocyclic compounds, including some amines, are carcinogenic. This book details the proposed mechanisms of Gewald-like reactions and the wide scope of substituted 2-aminothiophenes for real life applications. Literary information about synthesis methods, structure, physical-chemical and biological properties is summarised, and also information about conversion of adamantyl-1 and adamantyl-2 imidazole and benzimidazole derivatives is given. In addition, 3-acetylindole derivatives have been in the centre of attention of researchers over many years due to the high practical value of these compounds. This book presents a survey of the literature on 3-acetylindoles chemistry and provides useful and up-to-date data for medicinal chemists.

✦ Table of Contents

HETEROCYCLIC COMPOUNDS: SYNTHESIS, PROPERTIES AND APPLICATIONS......Page 3
HETEROCYCLIC COMPOUNDS: SYNTHESIS, PROPERTIES AND APPLICATIONS......Page 5
CONTENTS......Page 7
PREFACE......Page 9
PEER REVIEW......Page 15
ABSTRACT......Page 16
ABBREVIATIONS......Page 17
1. INTRODUCTION......Page 18
2. SYNTHESIS......Page 19
2.1. The First Version of the Gewald Reaction......Page 20
2.2. The Second Version of the Gewald Reaction......Page 21
2.3. The Third Version of the Gewald Reaction......Page 22
2.4. The Fourth Version of the Gewald Reaction......Page 23
2.5. Mechanism of the Gewald Reaction......Page 24
2.6. Modifications of the Gewald Reaction......Page 28
3. REACTIONS OF 2-AMINOTHIOPHENES......Page 35
3.1. Synthesis of Substituted thieno 3,4-c thiolactones......Page 36
3.2. Synthesis of Substituted Thieno2,3-bpyrroles......Page 37
3.3. Synthesis of Substituted thieno 2,3-d pyrimidines......Page 38
3.4. Synthesis of Substituted Thieno 2,3-b pyridines......Page 39
4. APPLICATIONS OF 2-AMINOTHIOPHENES......Page 40
4.1. Synthesis of Pharmaceuticals and Drugs......Page 41
4.2. Synthesis of Building Blocks for Opto-electronic Devices,Sensors and Self-assembled Superstructures......Page 47
4.3. SYNTHESIS OF SOME DISPERSEDTHIOPHENE-BASED AZO DYES......Page 49
6. ACKNOWLEDGMENT......Page 50
7. REFERENCES......Page 51
ABSTRACT......Page 61
INTRODUCTION......Page 62
ADAMANTYLIMIDAZOLES: SYNTHESIS, PROPERTIES......Page 63
ADAMANTYLBENZIMIDAZOLES: SYNTHESIS, PROPERTIES......Page 79
REFERENCES......Page 101
ABSTRACT......Page 113
INTRODUCTION......Page 114
EXPERIMENTAL PART......Page 126
ACKNOWLEGEMENT......Page 130
REFERENCES......Page 131
ABSTRACT......Page 133
INTRODUCTION......Page 134
1. MACROCYCLES ON THE BASIS OF 1,2-DISUBSTITUTED BENZENE......Page 136
2. MACROCYCLES COMPRISING 1,3-DISUBSTITUTEDBENZENE FRAGMENT......Page 139
3. MACROCYCLES CONTAINING 2,6-DISUBSTITUTEDPYRIDINE MOIETY......Page 141
4. MACROCYCLES WITH 3,5-DISUBSTITUTEDPYRIDINE SPACER......Page 143
5. INTRODUCTION OF 2,4- AND 4,6-DISUBSTITUTED PYRIMIDINE MOIETY......Page 147
6. MACROCYCLES DERIVED FROM 4,4'- AND 3,3'-DIBROMOBIPHENYLS......Page 149
7. INTRODUCTION OF NAPHTHALENE MOIETIES INTOPOLYAZAMACROCYCLES......Page 152
8. ANTHRACENE- AND ANTHRAQUINONE-BASEDPOLYAZA- AND POLYAZAPOLYOXAMACROCYCLES......Page 153
REFERENCES......Page 156
ABSTRACT......Page 161
SYNTHESIS OF ISOMERIC PYRIDAZINOINDOLES......Page 162
2. SYNTHESIS, CHEMICAL PROPERTIES AND PHARMACOLOGICAL ACTIVITY OF THE DERIVATIVES OF PYRIDAZINOINDOLES......Page 173
REFERENCES......Page 179
ABSTRACT......Page 185
RESULTS AND DISCUSSION......Page 186
EXPERIMENTAL......Page 191
REFERENCES......Page 195
ABSTRACT......Page 197
INTRODUCTION......Page 198
3-(p-Chlorophenylazo)-1H,10H-benzo[e]pyrrolo[3,2-g]indole (VII)......Page 205
2-Phenylazo-3H,8H-indolo[4,5-e]indole (XI).......Page 206
3,8-Diformyl-1H,10H-benzo[e]pyrrolo[3,2-g]indole (XV)......Page 207
3,8-Diallylindolo[5,4-e]indole (XVIII)......Page 208
3,8-Diallylindolo[4,5-e]indole (XXII).......Page 209
EXPERIMENTAL BIOLOGICAL PART......Page 210
REFERENCES......Page 214
ABSTRACT......Page 215
INTRODUCTION......Page 216
EXPERIMENTAL PART......Page 218
REFERENCES......Page 223
2-PYRIDINESELENENYL- AND TELLURENYL CHLORIDES AS BUILDING BLOCKS FOR DERIVATIVES OF 2,3-DIHYDRO[1,3] SELEN(TELLUR)AZOLO[3,2-A]PYRIDIN-4-IUM......Page 225
REFERENCES......Page 230
ABSTRACT......Page 233
INTRODUCTION......Page 234
EXPERIMENTAL PART......Page 236
REFERENCES......Page 238
ABSTRACT......Page 239
INTRODUCTION......Page 240
1.1. Photolysis Products and Quantum Yields......Page 244
1.2. Quantum-chemical Calculations......Page 250
1.3. Relative Reactivity of Azido Groups in Polyazidopyridines......Page 255
2.1. Structure of 9-azidoacridine......Page 258
2.2. Spectral Properties of 9-azidoacridine......Page 267
2.3. Photochemical Properties of 9-azidoacridine......Page 270
2.4. Spectral and Photochemical Properties of 9-(4'-azidophenyl)acridine......Page 273
3. THEORETICAL INVESTIGATION OF THE HIGHER HETEROCYCLIC AZIDES......Page 280
4. LONG-WAVELENGTH BOUNDARY OF AROMATIC AZIDE PHOTOACTIVITY......Page 292
5. PHOTOCHEMISTRY OF AZIDOSTYRYLQUINOLINES......Page 298
6. SIZE AND CHARGE EFFECTS IN HETEROCYCLIC AZIDE PHOTOCHEMISTRY......Page 304
7. LOW-TEMPERATURE PHOTOLYSIS OF HETEROAROMATIC AZIDES. HIGH-SPIN NITRENES......Page 309
8. PHOTOAFFINITY LABELING......Page 316
CONCLUSION......Page 320
REFERENCES......Page 321
1. INTRODUCTION......Page 331
2. 1. Bridgehead Nitrogen Thiazolopyrimidines......Page 332
2.3. Thiazolo[4,5-d]Pyrimidines......Page 363
2.4. Thiazolo[5,4-D]Pyrimidines......Page 377
3. MEDICINAL APPLICATIONS......Page 380
4. REFERENCES......Page 383
INDEX......Page 391

✦ Subjects

Химия и химическая промышленность;Органическая химия;Химия гетероциклических соединений;