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Heterocyclic compound studies. II. Synthesis of 1,4-benzodioxin, 1,4-benzoxathiin, 1,4-benzoxazine and 1,4-benzothiazine derivatives

โœ Scribed by Salvatore Cabiddu; Costantino Floris; Stefana Melis; Francesca Sotgiu; Giovanni Cerioni


Book ID
112128433
Publisher
Journal of Heterocyclic Chemistry
Year
1986
Tongue
English
Weight
478 KB
Volume
23
Category
Article
ISSN
0022-152X

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Solid-phase combinatorial synthesis of 1
โœ Cheng Leng Lee; Kok Ping Chan; Yulin Lam; Soo Ying Lee ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th