Heterocyclic aromatic amines form high levels of DNA adducts in human hepatocytes
β Scribed by G.C. Nauwelaers; D. Gu; V. Fessard; R. Turesky; S. Langouet
- Book ID
- 116923981
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 56 KB
- Volume
- 205
- Category
- Article
- ISSN
- 0378-4274
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCAβ7 cells, highly expressing isoform COXβ2, we investigated the effects of PUFA on
## Abstract Foodβderived heterocyclic aromatic amines (HCAs) have proved to be carcinogenic in both rodents and nonhuman primates. Two different metabolic pathways are suggested for the metabolic activation of HCA. The hepatic pathway proceeds via a twoβstep process involving __N__βhydroxylation by