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Hetero-oligomerization does not compromise ‘gain of function’ of tumor-derived p53 mutants

✍ Scribed by Deb, Debabrita; Scian, Mariano; Roth, Katherine E; Li, Wei; Keiger, Jane; Chakraborti, Abhay Sankar; Deb, Swati Palit; Deb, Sumitra

Book ID: 110066260
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 421 KB
Volume: 21
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1205035

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## Abstract Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate‐induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53^–