Hetero-Multifunctional Poly(ethylene glycol) Copolymers with Multiple Hydroxyl Groups and a Single Terminal Functionality
✍ Scribed by Christine Mangold; Frederik Wurm; Boris Obermeier; Holger Frey
- Book ID
- 102493663
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 266 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
Hetero‐multifunctional poly(ethylene glycol‐co‐glycerol) random copolymers with multiple hydroxyl functionalities and a single terminal functionality have been prepared by copolymerization of ethylene oxide (EO) and ethoxy ethyl glycidyl ether (EEGE) with the use of a suitable initiator, introducing a protected amino group or a double bond, respectively. Acidic deprotection was used for removal of the acetal protecting groups in the chain, and the terminal amino group was regenerated by catalytic hydrogenation. A series of copolymers with narrow polydispersity was obtained, varying comonomer fractions from 3 to 67% and molecular weights in the range of 5 000–32 000 g · mol^−1^ (1.05 < $\overline M _{\rm w} /\overline M _{\rm n}$ < 1.25). Molecular and thermal characterization was carried out using ^1^H‐ and ^13^C NMR, SEC and differential scanning calorimetry (DSC).
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