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Hetero-association of caffeine and theophylline with purine and pyrimidine in aqueous solutions studied by 1H NMR chemical shift measurements

✍ Scribed by Ferenc Aradi; András Földesi


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
320 KB
Volume
27
Category
Article
ISSN
0749-1581

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The interaction of caffeine and theophylline with sodium benzoate and sodium salicylate has been studied in deuterium oxide at 35°C by measnring the aromatic salt-induced changes in the chemical shifts of the N-methyl protons. Taking into account the self-association of the N-methylxanthines, on the

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## Abstract The self‐association of pyrimidine and its methylated derivatives was studied by measuring the concentration‐dependent changes in proton chemical shifts in deuterium oxide at 35°C. The data were analysed by a dimer model with two parameters. The equilibrium constants give an increasing