Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2
β Scribed by Jhabvala-Romero, Farida; Evans, Adam; Guo, Shuhua; Denton, Michael; Clinton, Gail Mary
- Book ID
- 110067997
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 282 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Two members of the EGF receptor family, HER2 and HER3, act as key oncogenes in breast cancer cells. A MAb against HER2, trastuzumab, interferes with HER2 signaling and istherapeutically effective in humans. Here, we explored the biologic effects of an antibody against HER3 (Ξ±βHER3^ECD^)
## Abstract Although tamoxifen (TAM) is used for the frontβline treatment and prevention of estrogen receptorβpositive (ER+) breast tumors, nearly 40% of estrogenβdependent breast tumors do not respond to TAM treatment. Moreover, the positive response is usually of short duration, and most tumors e