## Abstract Kaposi's sarcoma (KS) accounts for more than 15% of AIDSโrelated malignancies. The etiology of KS is unresolved but is postulated to be multiโfactorial, involving viruses and overexpression of cellular growth factors and/or oncogenes. Recently, herpesvirusโlike sequences (KSHV) were ide
Herpesvirus-like DNA sequences in Japanese patients with AIDS-related kaposi's sarcoma
โ Scribed by Natsuo Tachikawa; Mieko Goto; Hiroyuki Gatanaga; Harutaka Katano; Shinichi Oka; Tomo Wakabayashi; Shigeo Mori; Aikichi Iwamoto
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 352 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1341-321X
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Kaposi's sarcoma (KS) is a malignancy suspected of having an infectious etiology. Unique viral DNA sequences were recognized in KS lesions, using a novel technique that identifies small differences between two complex genomes. The virus had homology with the herpesvirus family, especially Epstein Ba
The evidence of an infectious agent other than human immunodeficiency virus (HIV) acting as a possible etiologic cause of Kaposi's sarcoma (KS) has received considerable attention in the last years. Recently, DNA sequences from a new herpesvirus (HHV-8) have been observed in several cases of KS. The
The identification of Kaposi's sarcoma (KS) clusters in subequatorial Africa (endemic KS, AKS) and the high frequency of KS in sexually transmitted AIDS (epidemic KS, EKS), have previously suggested a role for infectious agents in the etiopathogenesis of KS. The recent identification of herpesvirus
## Abstract We report the molecular characterization of 38 new Kaposi's sarcomaโassociated herpesvirus (KSHV) strains from Russian patients with either classic (25 cases), epidemic/AIDSโassociated (7 cases), or posttransplant/immunosuppressed patients (6 cases), or Kaposi's sarcoma (KS). While a co