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Herpes thymidine kinase inhibitors: Resolution and enantioselective synthesis of L-653,180 and water-soluble prodrugs

✍ Scribed by D.J. Von Langen; J.D. Karkas; R. Bostedor; R. Liou; R.L. Tolman

Book ID: 113259319
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 73 KB
Volume: 26
Category: Article
ISSN: 0166-3542
DOI: 10.1016/0166-3542(95)94849-w

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✍ Derek J. Von Langen; R.L. Tolman 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 292 KB

Resolution of L-653180, (\_+)-9-{[(Z)-2-(hydroxymethyl)cyclohexyl]-methyl}guanine, a racemic, nonsubstrate inhibitor of HSV-TK, was achieved and the absolute stereochemistry of the enantiomers was determined. Enzyme inhibition was shown to reside in the enantiomer with [1S,2R] stereochemistry in the