Herpes simplex virus type 1 and Alzheimer’s disease: The autophagy connection
✍ Scribed by Ruth F. Itzhaki; S. Louise Cosby; Matthew A. Wozniak
- Book ID
- 111739480
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 76 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1355-0284
No coin nor oath required. For personal study only.
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## Abstract A viral aetiology has long been suspected for Alzheimer's disease (AD) but until now, techniques have not been sufficiently sensitive to provide clear evidence for or against the presence of any viral genome in AD brain. We have used the very highly sensitive method of polymerase chain
## Abstract It was previously shown that herpes simplex virus type 1 (HSV1) DNA resides latently in a high proportion of aged brains and that in carriers of the type 4 allele of the apolipoprotein E gene (APOE‐ε4), it confers a strong risk of Alzheimer's disease. It was suggested that initial entry