Herpes simplex virus-induced cardiomyopathy successfully treated with acyclovir
โ Scribed by Petr Kuchynka; Tomas Palecek; Hana Hrbackova; Ivana Vitkova; Stanislav Simek; Eduard Nemecek; Viktor Aster; William E. Louch; Michael Aschermann; Ales Linhart
- Publisher
- Springer Vienna
- Year
- 2010
- Tongue
- English
- Weight
- 310 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0043-5325
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Recurrent acyclovir (ACV)-resistant (ACV-r) herpes simplex virus type 1 (HSV-1) infections occurred in a patient with Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency syndrome composed of three clinical characteristics of immunodeficiency, thrombocytopenia, and an eczematous dermatit
inhibitors of the ribonucleotide reductase of herpes simplex viruses (HSV) potentiate the activity of acyclovir in vitro and in animal studies. In addition, the combination of the ribonucleotide reductase inhibitor 348U87 and acyclovir has synergistic therapeutic effects against infections in mice d