Herpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours
✍ Scribed by Craig McCormick; Gillian Duncan; Frank Tufaro
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 260 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1052-9276
No coin nor oath required. For personal study only.
✦ Synopsis
To gain entry into the host, viruses use host cell surface molecules that normally serve as receptors for other ligands. Herpes simplex virus type 1 (HSV-1) uses heparan sulphate (HS) glycosaminoglycans (GAGs) as receptors for initial attachment to the host cell surface. HS GAGs are both ubiquitous and structurally diverse, and normally serve as critical mediators of interactions between the cell and the extracellular environment. We have used the HS binding ability of HSV-1 to identify the function of a cellular gene, EXT1, which is involved in HS polymerisation. Cellular factors that affect virus growth and replication are often key regulators of the cell cycle and EXT1 is no differentÐhumans with inherited mutations in EXT1 have developmental defects that lead to bone tumours (hereditary multiple exostoses, HME) and sometimes chondrosarcomas. Thus, as a result of using HSV-1 as a molecular probe, a functionally orphaned disease gene now has a de®ned function. These ®ndings highlight the utility of viruses for investigating important cellular processes.