Herpes simplex virus as a model vector system for gene therapy in renal disease

Adenovirus-mediated herpes simplex virus

Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer

✍ Simon J. Hall; Steven E. Mutchnik; Shu-Hsia Chen; Savio L.C. Woo; Timothy C. Tho 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 106 KB 👁 2 views

It is critical to develop new therapies, such as gene therapy, which can impact on both local and metastatic prostate cancer progression. We have developed an orthotopic mouse model of metastatic prostate cancer using a cell line (RM-1) derived from the mouse prostate reconstitution (MPR) model syst