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Heroin increases the density and sensitivity of platelet α2-adrenoceptors in human addicts

✍ Scribed by Jesús A. García-Sevilla; Luisa Ugedo; Isabel Ulibarri; Miguel Gutierrez

Publisher
Springer
Year
1986
Tongue
English
Weight
446 KB
Volume
88
Category
Article
ISSN
0033-3158

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✦ Synopsis

The density of platelet c~z-adrenoceptors, quantified by means of the binding of [3H]clonidine, and the aggregation response induced by adrenaline, was investigated in ten heroin addicts. The number of binding sites for [3H]clonidine was significantly increased during heroin abuse. Concomitantly, there was a potentiation of the adrenaline-induced platelet aggregation, which suggested that continuous heroin use (opiate dependence) is associated with supersensitive platelet c~2-adrenoceptors in human addicts. Spontaneous heroin withdrawal further increased in the same addicts the density of platelet c~2-adrenoceptors. These results suggest that platelet e2-adrenoceptots may be used as a model to study receptor mechanisms of opiate dependence and withdrawal in humans

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