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Heregulin-Induced VEGF Expression via the ErbB3 Signaling Pathway in Colon Cancer

✍ Scribed by Yonezawa, Masaoki; Wada, Ken; Tatsuguchi, Atsushi; Akamatsu, Tomonori; Gudis, Katya; Seo, Tsuguhiko; Mitsui, Keigo; Nagata, Kazuhiro; Tanaka, Shu; Fujimori, Shunji; Sakamoto, Choitsu

Book ID: 121202913
Publisher: S. Karger AG
Year: 2009
Tongue: English
Weight: 591 KB
Volume: 80
Category: Article
ISSN: 0012-2823
DOI: 10.1159/000229775

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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/