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Heregulin-induced epigenetic regulation of the utrophin-A promoter

✍ Scribed by Utpal Basu; Mads Gyrd-Hansen; Santhosh M. Baby; Olga Lozynska; Thomas O.B. Krag; Claus J. Jensen; Morten Frödin; Tejvir S. Khurana

Book ID
118442581
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
839 KB
Volume
581
Category
Article
ISSN
0014-5793

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The AU565 breast carcinoma cell line was used to determine the role of the extracellular-regulated kinase (ERK) pathway in mediating Heregulin␤1 (HRG␤1)-induced mammary cell differentiation. ERK activation remained elevated for 2 h following high doses of HRG which induce differentiation. In contras