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Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance

✍ Scribed by Josef Finsterer; Wolfgang Löscher; Stefan Quasthoff; Julia Wanschitz; Michaela Auer-Grumbach; Giovanni Stevanin


Book ID
119304481
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
694 KB
Volume
318
Category
Article
ISSN
0022-510X

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Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterised by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia linked to the SPG3A locus on chromosome 14q11-2