## Abstract **Background:** Autosomal recessive hereditary spastic paraplegia with thin corpus callosum is a neurodegenerative disorder characterized by spastic paraparesis, cognitive impairment, and peripheral neuropathy. The neuroradiologic hallmarks are thin corpus callosum and periventricular w
Hereditary spastic paraplegia associated with dopa-responsive parkinsonism
✍ Scribed by Federico Micheli; María Graciela Cersósimo; Carlos Zúñiga Ramírez
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 46 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
A 47-year-old patient with hereditary spastic paraplegia and parkinsonian features is reported. Treatment with levodopa led to marked improvement in his neurological status and quality of life. However, several years later he developed motor fluctuations and dyskinesias. The latter promptly remitted with amantadine treatment.
📜 SIMILAR VOLUMES
We report on a patient who developed acute parkinsonian symptoms following shunt revision for hydrocephalus. Parkinsonism improved dramatically after levodopa therapy. Furthermore, there was no recurrence of Parkinsonism despite discontinuation of levodopa. This observation suggests that Parkinsonis
## Abstract Our objective was to estimate the frequency as well as to establish the clinical and neuroimaging profile of hereditary spastic paraplegia with thin corpus callosum (HSP‐TCC). HSP‐TCC was recognized as a specific clinical subtype of HSP and mapped to chromosome (ch) 15q13‐15 in Japanese
## Abstract Spastic paraplegias (HSPs) and dystonias (DYTs) typically localize to different neuroanatomic systems. We report clinical and genetic data from large Ohio kindred with autosomal dominant (AD) HSP and DYT. Single and multipoint linkage using microsatellite and single nucleotide polymorph