Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations
β Scribed by E Thompson; CJ Meldrum; R Crooks; M McPhillips; L Thomas; AD Spigelman; RJ Scott
- Book ID
- 110887883
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 103 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0009-9163
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We have screened 17 Southern Sweden individuals/families with suspected hereditary non-polyposis colorectal cancer (HNPCC) for mutations in the DNA-mismatch repair genes hMLH1, hMSH2 and hMSH6 using denaturing gradient gel electrophoresis, protein truncation test and direct DNA sequencing. The famil
Hereditary non-polyposis colorectal cancer (HNPCC), the most common hereditary colon cancer syndrome, is a dominant disorder caused by germline defects in mismatch repair (MMR) genes. Identification of MMR gene mutations can have direct clinical implications in counseling and management of HNPCC fam