Hereditary diffuse gastric cancer: translation ofCDH1germline mutations into clinical practice

Novel germline CDH1 mutations in heredit

Novel germline CDH1 mutations in hereditary diffuse gastric cancer families

✍ Bostjan Humar; Tumi Toro; Francesco Graziano; Hansjakob Müller; Zuzana Dobbie; H 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 414 KB

Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.