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Hereditary Diffuse Gastric Cancer: A Family Diagnosis and Treatment

✍ Scribed by Onitilo, A. A.; Aryal, G.; Engel, J. M.


Book ID
120033930
Publisher
Marshfield Clinic Research Foundation
Year
2012
Tongue
English
Weight
460 KB
Volume
11
Category
Article
ISSN
1539-4182

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## Abstract ## BACKGROUND. A subset of patients with diffuse gastric cancer harbor deleterious cancer‐causing germline mutations in the type 1 E‐cadherin (epithelial) gene (__CDH1__), which predisposes to the autosomal dominantly inherited hereditary diffuse gastric cancer (HDGC) syndrome. These m

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Hereditary diffuse gastric cancer (HDGC) is a recently defined cancer syndrome caused by inactivating, heterozygous germline mutations in the gene for the cell-to-cell adhesion protein E-cadherin (CDH1). Here, we describe the search for CDH1 mutations in 10 newly identified gastric cancer families.