Hereditary chondrocalcinosis in a mexican-american family

✍ Scribed by Bruce C. Richardson; Neil I. Chafetz; Linda D. Ferrell; Julian I. Zulman; Harry K. Genant

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 863 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780261112

✦ Synopsis

In a study of 45 adults in a family of Mexican-Indian ancestry, it was found that 22 (49%) had joint symptoms resembling those of degenerative joint disease. Eleven family members had radiographic evidence of chondrocalcinosis, and 1 adult and 3 adolescents had clinical histories and examinations consistent with the familial arthropathy, but no radiographic evidence of disease. The cause of the arthritis in the affected family members is calcium pyrophosphate crystal deposition. The mode of inheritance appears to be autosomal dominant with a high degree of penetrance. The disease is characterized by onset in the second to fifth decades of either episodes of acute inflammatory arthritis or degenerative joint disease. A unique finding of this study was a "halo" surrounding chondrocytes in 1 patient's cartilage, demonstrating loss of the proteoglycans.

Hereditary chondrocalcinosis has been described in families from Canada ( I ) , Czechoslovakia (2), Holland (3), Spain (4), Chile (5). France (6), and Sweden (7). Three clinical forms have been noted. The first, characterized by early onset and a relapsing mild From the