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HER2/CEP17 ratio and HER2 immunohistochemistry predict clinical outcome after first-line trastuzumab plus taxane chemotherapy in patients with HER2 fluorescence in situ hybridization-positive metastatic breast cancer

✍ Scribed by Ji-Won Kim, Jee Hyun Kim, Seock-Ah Im, Yu Jung Kim…

Book ID
120776042
Publisher
Springer
Year
2013
Tongue
English
Weight
261 KB
Volume
72
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND: Only a portion of breast cancer patients currently selected for trastuzumab therapy respond. ## METHODS: Using a novel assay (HERmark) to quantify total human epidermal growth factor receptor 2 (HER2) expression, the authors examined outcomes in 102 trastuzumab‐treated