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HER2 therapy. Small molecule HER-2 tyrosine kinase inhibitors

✍ Scribed by Neil Spector, Wenle Xia, Iman El-Hariry, Yossi Yarden…

Book ID
120700306
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
324 KB
Volume
9
Category
Article
ISSN
1465-5411

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## Abstract The ultimate biological and clinical meaning of shed HER2 extracellular domain (ECD) has remained largely unclear until recently. Oversecretion of soluble HER2 ECD has been shown to inhibit growth of HER2‐overexpressing cancer cells by promoting HER2 ECD dimerization with HER transmembr