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Hepcidin Is Down-regulated in Alcoholic Liver Injury: Implications for the Pathogenesis of Alcoholic Liver Disease

โœ Scribed by Kim R. Bridle; Ting-Kin Cheung; Therese L. Murphy; Margaret M. Walters; Gregory J. Anderson; Darrell H. G. Crawford; Linda M. Fletcher

Book ID
109123406
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
650 KB
Volume
30
Category
Article
ISSN
0145-6008

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Alcohol reduces and iron increases liver hepcidin synthesis. This study investigates the interaction of alcohol and iron in the regulation of hepcidin messenger RNA (mRNA) expression in animal models. Mice were administered 10% ethanol for 7 days after an iron-overloaded diet. Rats were administered