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Hepatotoxin Rubratoxin B Induced the Secretion of TNF-α, IL-8, and MCP-1 in HL60 Cells

✍ Scribed by Hitoshi Nagashima; Kumiko Nakamura; Tetsuhisa Goto


Book ID
115588710
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
50 KB
Volume
287
Category
Article
ISSN
0006-291X

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The promyelocytic HL 60 cell line can be used as an in vitro model system to study hematopoetic cell differentiation and inflammatory events. We studied the signal transduction pathway of induced interleukin (IL)-8 expression and compared it with those of tumor necrosis factor alpha (TNF-a), IL-l a,