Hepatotoxicity of acetaminophen in neonatal and young rats: I. Age-related changes in susceptibility
โ Scribed by M.D. Green; T.K. Shires; L.J. Fischer
- Book ID
- 113206370
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 731 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0041-008X
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## Abstract The contribution of gastrointestinal tract (GIT), liver, and lung towards the firstโpass metabolism of acetaminophen was examined using 3โweekโold, 10โweekโold and 1โyearโold rats after administration of 30mgkg^โ1^ doses by intraโarterial, intravenous, intraperitoneal, and oral routes.
## Abstract A multiโage rat model was evaluated as a means to identify a potential ageโrelated difference in liver injury following exposure to valproic acid (VPA), a known pediatric hepatotoxic agent. Different age groups of SpragueโDawley (SD) rats (10โ, 25โ, 40โ, 80โdayโold) were administered VP